Protein Details: Aquaporin-5

Protein ID

ICDB_Pro_1693

Protein Name

Aquaporin-5

Gene Name

Aqp5

Organism

Mus musculus (Mouse)

Length

265 amino acids

AlphaFoldDB

AF-Q9WTY4-F1-model_v4.pdb

Function

Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4;controls regulatory volume decrease in salivary epithelial cells . Seems to play a redundant role in water transport in the eye;lung and in sweat glands.

Sequence

MKKEVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSHWVFWVGPIVGAVLAAILYFYLLFPSSLSLHDRVAVVKGTYEPEEDWEDHREERKKTIELTAH

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Sepsis; edema

Location

Detected at the luminal membrane of secretory epithelial cells in hindpaw sweat glands (PubMed:12042359;PubMed:23473857). Detected in acinar cells in salivary glands;in duct cells in lacrimal glands and in lung (at protein level) (PubMed:10337625;PubMed:10400615;PubMed:10619865;PubMed:16571723;PubMed:18027168). Detected in lung;parotid;submandibular;sublingual;and lacrimal gland tissues (PubMed:10337625). Detected in lung;parotid;submandibular;sublingual;and lacrimal gland tissues (PubMed:10337625). Detected in lung;parotid;submandibular;sublingual;and lacrimal gland tissues (PubMed:10337625).

DOI ID

10.1007/s003359901030; 10.1126/science.1112014; 10.1074/jbc.274.29.20071; 10.1172/jci8258; 10.1113/jphysiol.2001.020180; 10.1074/jbc.m600549200; 10.1080/02713680701733076; 10.1016/j.cell.2010.12.001; 10.1016/j.jdermsci.2013.01.013

RefSeq

NP_033831.1